Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta.

@article{Ballock1994InhibitionOT,
  title={Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta.},
  author={Robert Tracy Ballock and Ahlke Heydemann and Lalage M. Wakefield and Kathleen C. Flanders and Anita B. Roberts and Michael B. Sporn},
  journal={Journal of cellular physiology},
  year={1994},
  volume={159 2},
  pages={340-6}
}
Retinoic acid has been identified as a key morphogen governing pattern formation in the developing cartilaginous skeleton. Retinoids have also been implicated in the premature closure of the cartilage growth plate following vitamin A intoxication or administration of retinoids for dermatologic conditions. Previous studies of the mechanism of action of retinoids in non-chondrogenic cells have concluded that retinoic acid is a negative regulator of AP-1 responsive metalloprotease genes. We show… CONTINUE READING

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