Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin.

@article{Gschwendt1983InhibitionOT,
  title={Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin.},
  author={Michael Gschwendt and Friedemann Horn and Walter Kittstein and Friedrich Marks},
  journal={Biochemical and biophysical research communications},
  year={1983},
  volume={117 2},
  pages={444-7}
}
The flavonoid quercetin is a potent inhibitor of calcium- and phospholipid-dependent protein kinase (Ca, PL-PK) activity from mouse brain. Half-maximal inhibition of the kinase occurs at about 10 microM. If the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) is used instead of calcium as a stimulating factor of the kinase enzyme activity is still inhibited by quercetin. The kinase inhibitor, however, does not interfere with the binding of TPA to its receptor. 

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