Inhibition of the assembly and secretion of procollagen by incorporation of a threonine analogue, hydroxynorvaline.

@article{Christner1975InhibitionOT,
  title={Inhibition of the assembly and secretion of procollagen by incorporation of a threonine analogue, hydroxynorvaline.},
  author={P. Christner and A. Carpousis and M. Harsch and J. Rosenbloom},
  journal={The Journal of biological chemistry},
  year={1975},
  volume={250 19},
  pages={
          7623-30
        }
}
Hydroxynorvaline (DL-alpha-amino-beta-hydroxyvaleric acid) was shown to competitively inhibit the activation of threonine and valine when tested with tRNA and synthetases prepared from whole chick embryos. However, the hydroxynorvaline was transferred only to threonyl-tRNA and not valyl-tRNA. The hydroxynorvaline had no effect when tested with other amino acids. The Km for threonine was 25 muM and the Ki for hydroxynorvaline was 181 muM. When fibroblasts from embryonic chick tendons were… Expand
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