Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice

@article{Leinhase2007InhibitionOT,
  title={Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice},
  author={Iris Leinhase and Michal Rozanski and Denise Harhausen and Joshua M Thurman and Oliver I. Schmidt and Amir M. Hossini and Mohy E Taha and Daniel Rittirsch and Peter A Ward and V. Michael Holers and Wolfgang Ertel and Philip F. Stahel},
  journal={Journal of Neuroinflammation},
  year={2007},
  volume={4},
  pages={13 - 13}
}
The posttraumatic response to traumatic brain injury (TBI) is characterized, in part, by activation of the innate immune response, including the complement system. We have recently shown that mice devoid of a functional alternative pathway of complement activation (factor B-/- mice) are protected from complement-mediated neuroinflammation and neuropathology after TBI. In the present study, we extrapolated this knowledge from studies in genetically engineered mice to a pharmacological approach… CONTINUE READING

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Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation.

Proceedings of the National Academy of Sciences of the United States of America • 2006
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