Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling

@article{Stevison2017InhibitionOT,
  title={Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling},
  author={F. Stevison and C. Hogarth and S. Tripathy and Travis M. Kent and N. Isoherranen},
  journal={Drug Metabolism and Disposition},
  year={2017},
  volume={45},
  pages={846 - 854}
}
  • F. Stevison, C. Hogarth, +2 authors N. Isoherranen
  • Published 2017
  • Biology, Medicine
  • Drug Metabolism and Disposition
  • All-trans retinoic acid (atRA), the active metabolite of vitamin A, is a ligand for several nuclear receptors and acts as a critical regulator of many physiologic processes. The cytochrome P450 family 26 (CYP26) enzymes are responsible for atRA clearance, and are potential drug targets to increase concentrations of endogenous atRA in a tissue-specific manner. Talarozole is a potent inhibitor of CYP26A1 and CYP26B1, and has shown some success in clinical trials. However, it is not known what… CONTINUE READING
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