Inhibition of the adipose conversion of BALB/c 3T3 cells by 12-O-tetradecanoylphorbol-13-acetate: dependence on pH reduction via lactic acid production.

Abstract

The effect of modifying culture pH on the adipose conversion of BALB/c 3T3 cells was studied. We have previously shown that the tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA) stimulates cellular lactic acid production, lowers the pH of the culture medium, and inhibits differentiation in this system. We now report that addition or organic acids… (More)

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