Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules.


Net (Elk-3/SAP-2/Erp) is a transcription factor that is phosphorylated and activated by the Ras-extracellular signal-regulated kinase (Erk) signaling pathway and is involved in wound healing, angiogenesis, and tumor growth. In a cell-based screen for small molecule inhibitors of Ras activation of Net transcriptional activity, we identified a novel pyrazole… (More)
DOI: 10.1158/0008-5472.CAN-07-2674


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