Inhibition of the NMDA and AMPA receptor channels by antidepressants and antipsychotics

@article{Barygin2017InhibitionOT,
  title={Inhibition of the NMDA and AMPA receptor channels by antidepressants and antipsychotics},
  author={O. I. Barygin and E. Nagaeva and D. Tikhonov and Darya A. Belinskaya and N. Vanchakova and N. Shestakova},
  journal={Brain Research},
  year={2017},
  volume={1660},
  pages={58-66}
}
It is known that some antidepressants and antipsychotics directly inhibit NMDA-type ionotropic glutamate receptors. In this study we systematically studied action of seven drugs (Fluoxetine, Citalopram, Desipramine, Amitriptyline, Atomoxetine, Chlorpromazine, and Clozapine) on NMDA receptors and Ca2+-permeable and -impermeable AMPA receptors in rat brain neurons by whole-cell patch-clamp technique. Except for weak effect of fluoxetine, all drugs were virtually inactive against Ca2+-impermeable… Expand

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