Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus

  title={Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus},
  author={Tal I. Arnon and Hagit Achdout and Ofer Levi and Gal Markel and Nivin Saleh and Gil Katz and Roi Gazit and Tsufit Gonen-Gross and Jacob Hanna and Efrat Nahari and Angel Porgador and Alik Honigman and Bodo Plachter and Dror Mevorach and Dana G. Wolf and Ofer Mandelboim},
  journal={Nature Immunology},
Human cytomegalovirus, a chief pathogen in immunocompromised people, can persist in a healthy immunocompetent host throughout life without being eliminated by the immune system. Here we show that pp65, the main tegument protein of human cytomegalovirus, inhibited natural killer cell cytotoxicity by an interaction with the activating receptor NKp30. This interaction was direct and specific, leading to dissociation of the linked CD3ζ from NKp30 and, consequently, to reduced killing. Thus, pp65 is… CONTINUE READING
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