Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A

@article{Grover2010InhibitionOT,
  title={Inhibition of the NEMO/IKK$\beta$ association complex formation, a novel mechanism associated with the NF-$\kappa$B activation suppression by Withania somnifera’s key metabolite withaferin A},
  author={A. Grover and Ashutosh Shandilya and A. Punetha and V. Bisaria and D. Sundar},
  journal={BMC Genomics},
  year={2010},
  volume={11},
  pages={S25 - S25}
}
BackgroundNuclear Factor kappa B (NF-κB) is a transcription factor involved in the regulation of cell signaling responses and is a key regulator of cellular processes involved in the immune response, differentiation, cell proliferation, and apoptosis. The constitutive activation of NF-κB contributes to multiple cellular outcomes and pathophysiological conditions such as rheumatoid arthritis, asthma, inflammatory bowel disease, AIDS and cancer. Thus there lies a huge therapeutic potential… Expand
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