Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.

@article{Andres2019InhibitionOT,
  title={Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.},
  author={F. Andres and L. Iamele and T. Meyer and Jakob C St{\"u}ber and Florian Kast and E. Gherardi and H. Niemann and A. Pl{\"u}ckthun},
  journal={Journal of molecular biology},
  year={2019},
  volume={431 10},
  pages={
          2020-2039
        }
}
  • F. Andres, L. Iamele, +5 authors A. Plückthun
  • Published 2019
  • Medicine
  • Journal of molecular biology
  • MET, the product of the c-MET proto-oncogene, and its ligand hepatocyte growth factor/scatter factor (HGF/SF) control survival, proliferation and migration during development and tissue regeneration. HGF/SF-MET signaling is equally crucial for growth and metastasis of a variety of human tumors, but resistance to small-molecule inhibitors of MET kinase develops rapidly and therapeutic antibody targeting remains challenging. We made use of the designed ankyrin repeat protein (DARPin) technology… CONTINUE READING
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