Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo

@inproceedings{Judd2014InhibitionOT,
  title={Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo},
  author={Louise M. Judd and Treve R. Menheniott and Hui Ling and C. B. Jackson and Meegan Howlett and Anastasia Kalantzis and Waldemar Priebe and Andrew S. Giraud},
  booktitle={PloS one},
  year={2014}
}
Signal Transducer and Activator of Transcription-3 (STAT3) is constitutively activated in many cancers where it promotes growth, inflammation, angiogenesis and inhibits apoptosis. We have shown that STAT3 is constitutively activated in human gastric cancer, and that chronic IL-11-driven STAT3 transcriptional activity induces gastric tumourigenesis in the… CONTINUE READING