Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice

@article{Tang2010InhibitionOT,
  title={Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice},
  author={Y Tang and Dan P. Reay and Melessa N. Salay and Michael Y. Mi and Paula R. Clemens and Denis C. Guttridge and Paul D. Robbins and Johnny Huard and B Wang},
  journal={Gene Therapy},
  year={2010},
  volume={17},
  pages={1476-1483}
}
The IκB kinase (IKKα, β and the regulatory subunit IKKγ) complex regulates nuclear factor of κB (NF-κB) transcriptional activity, which is upregulated in many chronic inflammatory diseases. NF-κB signaling promotes inflammation and limits muscle regeneration in Duchenne muscular dystrophy (DMD), resulting in fibrotic and fatty tissue replacement of muscle that exacerbates the wasting process in dystrophic muscles. Here, we examined whether dominant-negative forms of IKKα (IKKα-dn) and IKKβ (IKK… CONTINUE READING
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