Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate.

@article{Wu1993InhibitionOT,
  title={Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate.},
  author={Jeffrey K Wu and Paul Dent and T Jelinek and Alan Wolfman and Michael D Weber and Thomas W. Sturgill},
  journal={Science},
  year={1993},
  volume={262 5136},
  pages={1065-9}
}
Mitogen-activated protein (MAP) kinases p42mapk and p44mapk are activated in cells stimulated with epidermal growth factor (EGF) and other agents. A principal pathway for MAP kinase (MAPK) activation by EGF consists of sequential activations of the guanine nucleotide exchange factor Sos, the guanosine triphosphate binding protein Ras, and the protein kinases Raf-1, MAPK kinase (MKK), and MAPK. Because adenosine 3',5'-monophosphate (cAMP) does not activate MAPK and has some opposing physiologic… CONTINUE READING
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