Corpus ID: 201663422

Inhibition of the Cell Growth in M Cells by Bi-Para

  title={Inhibition of the Cell Growth in M Cells by Bi-Para},
  author={F. Andres and L. Iamele and Timo Mey and Jakob C St{\"u}ber and Florian Kast and E. Gherardi and H. Niemann and A. Pl{\"u}ckthun},
  • F. Andres, L. Iamele, +5 authors A. Plückthun
  • Published 2019
  • MET, the product of the c-MET proto-oncogene, and its ligand hepatocyte growth factor/scatter factor (HGF/SF) control survival, proliferation andmigration during development and tissue regeneration. HGF/SF-MET signaling is equally crucial for growth and metastasis of a variety of human tumors, but resistance to small-molecule inhibitors of MET kinase develops rapidly and therapeutic antibody targeting remains challenging.Wemade use of the designed ankyrin repeat protein (DARPin) technology to… CONTINUE READING

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