Inhibition of the Cardiac Na+ Channel Nav1.5 by Carbon Monoxide*

  title={Inhibition of the Cardiac Na+ Channel Nav1.5 by Carbon Monoxide*},
  author={Jacobo Elies and Mark L. Dallas and John P Boyle and Jason L. Scragg and Adrian M. Duke and Derek Steele and Chris Peers},
  journal={The Journal of Biological Chemistry},
  pages={16421 - 16429}
Background: CO poisoning causes cardiac arrhythmias, in part via modulation of the cardiac Na+ channel, Nav1.5. Results: CO inhibition of peak recombinant Nav1.5 current occurs via nitric oxide formation and is also dependent on channel redox state. Conclusion: CO inhibits peak recombinant Nav1.5 current via a mechanism distinct from activation of the late Na+ current. Significance: CO may induce Brugada-like arrhythmias via inhibition of peak Na+ current. Sublethal carbon monoxide (CO… 

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