Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands.

@article{Li2001InhibitionOT,
  title={Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands.},
  author={Ji-liang Li and Rebecca J Harrison and Anthony P. Reszka and Robert M. Brosh and Vilhelm A. Bohr and Stephen Neidle and Ian D. Hickson},
  journal={Biochemistry},
  year={2001},
  volume={40 50},
  pages={
          15194-202
        }
}
G-Quadruplex DNAs are folded, non-Watson-Crick structures that can form within guanine-rich DNA sequences such as telomeric repeats. Previous studies have identified a series of trisubstituted acridine derivatives that are potent and selective ligands for G-quadruplex DNA. These ligands have been shown previously to inhibit the activity of telomerase, the specialized reverse transcriptase that regulates telomere length. The RecQ family of DNA helicases, which includes the Bloom's (BLM) and… CONTINUE READING
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