Inhibition of telomerase in the endothelial cells disrupts tumor angiogenesis in glioblastoma xenografts.

@article{Falchetti2008InhibitionOT,
  title={Inhibition of telomerase in the endothelial cells disrupts tumor angiogenesis in glioblastoma xenografts.},
  author={Maria Laura Falchetti and Maria Patrizia Mongiardi and Paolo Fiorenzo and Giovanna Petrucci and Francesco Pierconti and Igea D'agnano and Giorgio Quintino D'Alessandris and Giulio Alessandri and Maurizio Gelati and Lucia Ricci-Vitiani and G Maira and Luigi Maria Larocca and Andrea Levi and Roberto Pallini},
  journal={International journal of cancer},
  year={2008},
  volume={122 6},
  pages={1236-42}
}
Tumor angiogenesis is a complex process that involves a series of interactions between tumor cells and endothelial cells (ECs). In vitro, glioblastoma multiforme (GBM) cells are known to induce an increase in proliferation, migration and tube formation by the ECs. We have previously shown that in human GBM specimens the proliferating ECs of the tumor… CONTINUE READING