Inhibition of telomerase activity by dominant-negative hTERT retards the growth of breast cancer cells.


BACKGROUND Telomerase, a ribonucleoprotein enzyme mainly consisted of a catalytic protein subunit human telomerase reverse transcriptase (hTERT) and a human telomerase RNA component, is responsible for maintaining telomeres. Telomerase over-expression correlates significantly with tumors and is a prognostic marker. However, telomerase over-expression in… (More)
DOI: 10.1007/s12282-014-0553-z



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