Inhibition of taurine transport by cyclosporin A is due to altered surface abundance of the taurine transporter and is reversible.

@article{Tran2009InhibitionOT,
  title={Inhibition of taurine transport by cyclosporin A is due to altered surface abundance of the taurine transporter and is reversible.},
  author={Thanh Thuy Thi Tran and Xiaojun Qian and Cynthia Edwards and Hemanta K Sarkar},
  journal={Advances in experimental medicine and biology},
  year={2009},
  volume={643},
  pages={
          503-11
        }
}
We have investigated the underlying mechanism of the CsA-induced inhibition of taurine transport using a cell line permanently expressing the mouse taurine transporter (mTauT) tagged with the green-fluorescence protein (GFP). CsA inhibited the uptake activity of the expressed mTauT.GFP fusion protein in both dose and time dependent manner. Surface biotinylation assay revealed that the CsA-treatment reduced the relative surface abundance of the taurine transporter without affecting its total… CONTINUE READING