Inhibition of synaptosomal choline uptake by tetanus and botulinum a toxin

@article{Habermann1981InhibitionOS,
  title={Inhibition of synaptosomal choline uptake by tetanus and botulinum a toxin},
  author={Ernst Habermann and Hans Bigalke and Irmtraud Heller},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1981},
  volume={316},
  pages={135-142}
}
Tetanus toxin and, to a lesser degree, botulinum A toxin inhibit partially and noncompetitively the uptake of [3H]choline into a crude synaptosomal fraction from rat brain cortex. Botulinum toxin acts by its neurotoxin content. The effect is not due to nonspecific synaptosomal damage by the toxins as shown by the lactate dehydrogenase occlusion test, by the… CONTINUE READING