Inhibition of swelling-activated Cl- currents by functional anti-ClC-3 antibody in native bovine non-pigmented ciliary epithelial cells.

@article{Do2005InhibitionOS,
  title={Inhibition of swelling-activated Cl- currents by functional anti-ClC-3 antibody in native bovine non-pigmented ciliary epithelial cells.},
  author={Chi Wai Do and Wennan Lu and Claire H. Mitchell and Mortimer M. Civan},
  journal={Investigative ophthalmology \& visual science},
  year={2005},
  volume={46 3},
  pages={
          948-55
        }
}
PURPOSE To determine the potential role of ClC-3, a PKC-inhibitable Cl(-) channel, in mediating the swelling-activated Cl(-) current (I(Cl,swell)) of native bovine nonpigmented ciliary epithelial (NPE) cells. METHODS Native bovine NPE cells were freshly harvested by enzymatic digestion. Whole-cell currents were recorded by patch-clamp measurements either in the presence or absence of a functional anti-ClC-3 antibody. RESULTS Baseline whole-cell currents were small under isotonic conditions… 
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