Inhibition of survivin and aurora B kinase sensitizes mesothelioma cells by enhancing mitotic arrests.

@article{Kim2007InhibitionOS,
  title={Inhibition of survivin and aurora B kinase sensitizes mesothelioma cells by enhancing mitotic arrests.},
  author={Kwang Woon Kim and Robert W. Mutter and Christopher D Willey and Ty K. Subhawong and Eric T. Shinohara and Jeffrey M Albert and Geng Ling and Carolyn Cao and Young Jin Gi and Bo Lu},
  journal={International journal of radiation oncology, biology, physics},
  year={2007},
  volume={67 5},
  pages={1519-25}
}
PURPOSE Survivin, a member of the inhibitor of apoptosis gene family, has also been shown to regulate mitosis. It binds Aurora B kinase and the inner centromere protein to form the chromosome passenger complex. Both Aurora B and survivin are overexpressed in many tumors. In this study, we examined whether irradiation affected survivin and Aurora B expression in mesothelioma cells, and how inhibition of these molecules affected radiosensitivity. METHODS AND MATERIALS ZM447439 and survivin… CONTINUE READING

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