Inhibition of substrate oxidation in mitochondria by the peripheral-type benzodiazepine receptor ligand AHN 086.

Abstract

The effects, of the benzodiazepines RO5-4864, AHN 086, PK 11195 and clonazepam on respiration of mitochondria from heart, kidney, and liver were studied. ADP-stimulated respiration of heart mitochondria was the most sensitive to inhibition by AHN 086; clonazepam was not inhibitory. Several respiratory chain segment activities of submitochondrial particles… (More)

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@article{MorenoSnchez1991InhibitionOS, title={Inhibition of substrate oxidation in mitochondria by the peripheral-type benzodiazepine receptor ligand AHN 086.}, author={Roc{\'i}o del Pilar Moreno-S{\'a}nchez and Bonita Hogue and Carolina Bravo and Amy Hauck Newman and Adriana Basile and P. K. Chiang}, journal={Biochemical pharmacology}, year={1991}, volume={41 10}, pages={1479-84} }