Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide.

@article{Denekas2006InhibitionOS,
  title={Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide.},
  author={Thomas Denekas and Markus Tr{\"o}ltzsch and Axel Vater and Sven Klu\ssmann and Karl Messlinger},
  journal={British journal of pharmacology},
  year={2006},
  volume={148 4},
  pages={536-43}
}
Calcitonin gene-related peptide (CGRP) released from trigeminal afferents is known to play an important role in the control of intracranial blood flow. In a rat preparation with exposed cranial dura mater, periods of electrical stimulation induce increases in meningeal blood flow. These responses are due to arterial vasodilatation mediated in part by the release of CGRP. In this preparation, the effect of a CGRP-binding mirror-image oligonucleotide (Spiegelmer NOX-C89) was examined. Spiegelmer… CONTINUE READING

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