Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium.

@article{Zhang2014InhibitionOS,
  title={Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium.},
  author={Lan Zhang and Yaohua H Pan and Gangjian Qin and Lijuan Chen and Tapan Kumar Chatterjee and Neal L. Weintraub and Yaoliang Tang},
  journal={Cell cycle},
  year={2014},
  volume={13 5},
  pages={762-71}
}
Induced pluripotent stem cells (iPS) can differentiate into cardiomyocytes (CM) and represent a promising form of cellular therapy for heart regeneration. However, residual undifferentiated iPS derivates (iPSD), which are not fully eliminated by cell differentiation or purification protocols, may form tumors after transplantation, thus compromising therapeutic application. Inhibition of stearoyl-coA desaturase (SCD) has recently been reported to eliminate undifferentiated human embryonic stem… CONTINUE READING

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