Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain.

@article{Clark2007InhibitionOS,
  title={Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain.},
  author={Anna K Clark and Ping Kei Yip and John Grist and Clive Gentry and Amelia A Staniland and Fabien Marchand and Maliheh Dehvari and Glen Wotherspoon and Janet K. Winter and Jakir Ullah and Stuart Bevan and Marzia Malcangio},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 25},
  pages={10655-60}
}
A recent major conceptual advance has been the recognition of the importance of immune system-neuronal interactions in the modulation of brain function, one example of which is spinal pain processing in neuropathic states. Here, we report that in peripheral nerve-injured rats, the lysosomal cysteine protease cathepsin S (CatS) is critical for the maintenance of neuropathic pain and spinal microglia activation. After injury, CatS was exclusively expressed by activated microglia in the… CONTINUE READING
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