Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization.

@article{Li2007InhibitionOS,
  title={Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization.},
  author={Zhiqiang Li and Tiruneh K. Hailemariam and Hongwen Zhou and Yan Li and Dale C Duckworth and David A. Peake and Youyan Zhang and Ming-shang Kuo and Guoqing Cao and Xian-cheng Jiang},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1771 9},
  pages={1186-94}
}
Sphingomyelin plays a very important role both in cell membrane formation that may well have an impact on the development of diseases like atherosclerosis and diabetes. However, the molecular mechanism that governs intracellular and plasma membrane SM levels is largely unknown. Recently, two isoforms of sphingomyelin synthase (SMS1 and SMS2), the last enzyme for SM de novo synthesis, have been cloned. We have hypothesized that SMS1 and SMS2 are the two most likely candidates responsible for the… CONTINUE READING

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