Inhibition of sphingolipid synthesis impairs cellular activation, cytokine production and proliferation in human lymphocytes.

The localisation of the T cell receptor and other signalling molecules in membrane microdomains (MM) is essential for the activation of T lymphocytes. These MM are stabilized by sphingolipids and cholesterol. It was recently shown that the activation of T lymphocytes leads to the confluence of small MM and the formation of an immunological synapse which is… CONTINUE READING