Inhibition of specific pathways of myeloid cell differentiation by an activated Hox-2.4 homeobox gene.

@article{Blatt1992InhibitionOS,
  title={Inhibition of specific pathways of myeloid cell differentiation by an activated Hox-2.4 homeobox gene.},
  author={C F Blatt and Joseph Lotem and Leo Sachs},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1992},
  volume={3 10},
  pages={
          671-6
        }
}
Abnormal expression of homeobox genes is one of the abnormalities associated with the development of murine and human leukemia. Myeloid leukemic cells that can be induced to differentiate to mature cells by interleukin 6 were stably transfected with an activated Hox-2.4 homeobox gene. Expression of the Hox-2.4 gene in the transfected clones inhibited specific pathways of the myeloid differentiation program induced by interleukin 6. The expression of some genes associated with differentiation… CONTINUE READING
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