Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides.

@article{LpezVicario2015InhibitionOS,
  title={Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides.},
  author={Cristina L{\'o}pez-Vicario and Jos{\'e} Alcaraz-Quiles and Ver{\'o}nica Garc{\'i}a-Alonso and Bibiana Rius and Sung Hee Hwang and Esther Titos and Aritz Lopategi and Bruce D Hammock and Vicente Arroyo and Joan Cl{\`a}ria},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 2},
  pages={536-41}
}
Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases that have inflammation as a common underlying cause. sEH limits tissue levels of cytochrome P450 (CYP) epoxides derived from omega-6 and omega-3 polyunsaturated fatty acids (PUFA) by converting these antiinflammatory mediators into their less active diols. Here, we explored the metabolic effects of a sEH inhibitor (t-TUCB) in fat-1 mice with transgenic expression of an omega-3 desaturase capable of… CONTINUE READING
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