Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone

@article{Kernen1994InhibitionOS,
  title={Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone},
  author={T Ker{\"a}nen and Ariel Gordin and Mo Karlsson and Kirsi Korpela and Pertti J. Pentik{\"a}inen and Hannu J. Rita and Eija Schultz and L. Sepp{\"a}l{\"a} and T. Wikberg},
  journal={European Journal of Clinical Pharmacology},
  year={1994},
  volume={46},
  pages={151-157}
}
The inhibition of soluble catechol-O-methyltransferase (S-COMT) in red blood cells (RBCs) by entacapone, and the pharmacokinetics of entacapone after single oral (5–800 mg) and IV (25 mg) doses have been examined in an open study in 12 healthy young male volunteers. Oral entacapone dose-dependently decreased the activity of S-COMT in RBCs with a maximum inhibition of 82% after the highest dose (800 mg). The inhibition of S-COMT in RBCs was reversible and the activity recovered within 4–8 h… CONTINUE READING
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The inhibition of soluble catechol - O - methyltransferase ( S - COMT ) in red blood cells ( RBCs ) by entacapone , and the pharmacokinetics of entacapone after single oral ( 5–800 mg ) and IV ( 25 mg ) doses have been examined in an open study in 12 healthy young male volunteers .
The inhibition of soluble catechol - O - methyltransferase ( S - COMT ) in red blood cells ( RBCs ) by entacapone , and the pharmacokinetics of entacapone after single oral ( 5–800 mg ) and IV ( 25 mg ) doses have been examined in an open study in 12 healthy young male volunteers .
The inhibition of soluble catechol - O - methyltransferase ( S - COMT ) in red blood cells ( RBCs ) by entacapone , and the pharmacokinetics of entacapone after single oral ( 5–800 mg ) and IV ( 25 mg ) doses have been examined in an open study in 12 healthy young male volunteers .
The inhibition of soluble catechol - O - methyltransferase ( S - COMT ) in red blood cells ( RBCs ) by entacapone , and the pharmacokinetics of entacapone after single oral ( 5–800 mg ) and IV ( 25 mg ) doses have been examined in an open study in 12 healthy young male volunteers .
The inhibition of soluble catechol - O - methyltransferase ( S - COMT ) in red blood cells ( RBCs ) by entacapone , and the pharmacokinetics of entacapone after single oral ( 5–800 mg ) and IV ( 25 mg ) doses have been examined in an open study in 12 healthy young male volunteers .
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