Inhibition of soluble adenylyl cyclase increases the radiosensitivity of prostate cancer cells.

Abstract

Pharmacological modulation of tumor radiosensitivity is a promising strategy for enhancing the outcome of radiotherapy. cAMP signaling plays an essential role in modulating the proliferation and apoptosis of different cell types, including cancer cells. Until now, the regulation of this pathway was restricted to the transmembrane class of adenylyl cyclases… (More)
DOI: 10.1016/j.bbadis.2014.09.008

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