Inhibition of solar simulator-induced p53 mutations and protection against skin cancer development in mice by sunscreens.

@article{Ananthaswamy1999InhibitionOS,
  title={Inhibition of solar simulator-induced p53 mutations and protection against skin cancer development in mice by sunscreens.},
  author={Honnavara N. Ananthaswamy and Stephen E. Ullrich and Romano Mascotto and Anny Fourtanier and Susan M. Loughlin and Polina Khaskina and Corazon D. Bucana and Margaret L. Kripke},
  journal={The Journal of investigative dermatology},
  year={1999},
  volume={112 5},
  pages={763-8}
}
We demonstrated previously that p53 mutations can be detected in ultraviolet B-irradiated mouse skin months before the gross appearance of skin tumors and that applying sun protection factor 15 sunscreens to mouse skin before each Kodacel-filtered FS40 sunlamp irradiation resulted in the reduction of such mutations. To determine whether there is an association between reduction of ultraviolet-induced p53 mutations by sunscreens and protection against skin cancer using an environmentally… CONTINUE READING
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