Inhibition of skin inflammation in mice by diclofenac in vesicular carriers: liposomes, ethosomes and PEVs.

@article{Caddeo2013InhibitionOS,
  title={Inhibition of skin inflammation in mice by diclofenac in vesicular carriers: liposomes, ethosomes and PEVs.},
  author={Carla Caddeo and Octavio Diez Sales and Donatella Valenti and Amparo Ruiz Saur{\'i} and Anna Maria Fadda and Maria Manconi},
  journal={International journal of pharmaceutics},
  year={2013},
  volume={443 1-2},
  pages={128-36}
}
Diclofenac-loaded phospholipid vesicles, namely conventional liposomes, ethosomes and PEVs (penetration enhancer-containing vesicles) were developed and their efficacy in TPA (phorbol ester) induced skin inflammation was examined. Vesicles were made from a cheap and unpurified mixture of phospholipids and diclofenac sodium; Transcutol P and propylene glycol were added to obtain PEVs, and ethanol to produce ethosomes. The structure and lamellar organization of the vesicle bilayer were… CONTINUE READING

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