Inhibition of skeletal muscle protein synthesis in septic intra-abdominal abscess.

@article{Vary1988InhibitionOS,
  title={Inhibition of skeletal muscle protein synthesis in septic intra-abdominal abscess.},
  author={Thomas C. Vary and John H. Siegel and Ben D Tall and James G. Morris and Joyce A Smith},
  journal={The Journal of trauma},
  year={1988},
  volume={28 7},
  pages={981-8}
}
Chronic sepsis is always associated with profound wasting leading to increased release of amino acids from skeletal muscle. Net protein catabolism may be due to decreased rate of synthesis, increased rate of degradation, or both. To determine whether protein synthesis is altered in chronic sepsis, the rate of protein synthesis in vivo was estimated by measuring the incorporation of [3H]-phenylalanine in skeletal muscle protein in a chronic (5-day) septic rat model induced by creation of a… CONTINUE READING
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