Inhibition of shivering increases core temperature afterdrop and attenuates rewarming in hypothermic humans.

@article{Giesbrecht1997InhibitionOS,
  title={Inhibition of shivering increases core temperature afterdrop and attenuates rewarming in hypothermic humans.},
  author={Gordon Giesbrecht and M S Goheen and Chad E. Johnston and Glen P. Kenny and G. Bristow and John S Hayward},
  journal={Journal of applied physiology},
  year={1997},
  volume={83 5},
  pages={1630-4}
}
During severe hypothermia, shivering is absent. To simulate severe hypothermia, shivering in eight mildly hypothermic subjects was inhibited with meperidine (1.5 mg/kg). Subjects were cooled twice (meperidine and control trials) in 8 degrees C water to a core temperature of 35.9 +/- 0.5 (SD) degrees C, dried, and then placed in sleeping bags. Meperidine caused a 3.2-fold increase in core temperature afterdrop (1.1 +/- 0.6 vs. 0.4 +/- 0.2 degree C), a 4.3-fold increase in afterdrop duration (89… CONTINUE READING

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Clinical aspects of accidental hypothermia

  • G. K. Bristow
  • Physiological and Biochemical Adaptations,
  • 1985
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