Inhibition of shiga toxin cytotoxicity in human renal cortical epithelial cells by nitrobenzylthioinosine.

@article{Sekino2002InhibitionOS,
  title={Inhibition of shiga toxin cytotoxicity in human renal cortical epithelial cells by nitrobenzylthioinosine.},
  author={Takaomi Sekino and Nobutaka Kiyokawa and Tomoko Taguchi and Kazuhiro Ohmi and Hideki Nakajima and Toyo Suzuki and Susumu Furukawa and Hiroshi Nakao and Tae Takeda and Junichiro Fujimoto},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={185 6},
  pages={785-96}
}
Nitrobenzylthioinosine (NBTI), a nucleoside-transport inhibitor, has been found to possess the ability to prevent the cytotoxic action of Shiga toxin (Stx) 1 in human renal cortical epithelial cells (HRCECs), thereby protecting HRCECs from cell death. Further examination revealed that NBTI does not affect either the binding or the endocytosis of Stx1 but alters the intracellular transport of Stx1. Generally, endocytosed Stx1 is thought to be transported from endosomes to the endoplasmic… CONTINUE READING