Inhibition of sham feeding-stimulated human gastric acid secretion by glucagon-like peptide-2.

  title={Inhibition of sham feeding-stimulated human gastric acid secretion by glucagon-like peptide-2.},
  author={Morten W\ojdemann and Andr{\'e} Wettergren and Bolette Hartmann and Linda Maria Hilsted and Jens Juul Holst},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={84 7},
Glucagon-like peptide (GLP)-2 is formed from proglucagon in the intestinal L cells and is secreted postprandially in parallel with the insulinotropic hormone GLP-1, the latter of which, in addition, acts to inhibit gastric secretion and motility by inhibiting central parasympathetic outflow. We now studied the effect of GLP-2 on gastric secretion stimulated by sham feeding to test the hypothesis that also GLP-2 acts as an enterogastrone. Eight healthy volunteers were studied twice on separate… CONTINUE READING


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