Inhibition of serine proteases by anti-inflammatory triterpenoids.

@article{Raji2000InhibitionOS,
  title={Inhibition of serine proteases by anti-inflammatory triterpenoids.},
  author={Antonio Raji{\vc} and George Kweifio‐Okai and Theodore A. Macrides and Richard Mark Sandeman and David Spencer Chandler and Gideon Maxwell. Polya},
  journal={Planta medica},
  year={2000},
  volume={66 3},
  pages={
          206-10
        }
}
The lupane triterpenoid lupeol, the ursane triterpenoid alpha-amyrin and esters of these compounds are present in the bark of roots of Alstonia boonei (Apocynaceae) and have anti-inflammatory properties. alpha-Amyrin is a competitive inhibitor of bovine trypsin and chymotrypsin (Ki values 29 microM and 18 microM, respectively). Lupeol linoleate, lupeol palmitate and alpha-amyrin linoleate are non-competitive inhibitors of trypsin (Ki values 7 microM, 10 microM and 16 microM, respectively… 
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