Inhibition of sarthran-sensitive receptor in the rat rostral ventrolateral medulla reverses chronic Nω-nitro-L-arginine methyl ester-induced hypertension

@inproceedings{Hiratsuka2004InhibitionOS,
  title={Inhibition of sarthran-sensitive receptor in the rat rostral ventrolateral medulla reverses chronic Nω-nitro-L-arginine methyl ester-induced hypertension},
  author={Makoto Hiratsuka and Shinzaburo Ito and Yoshiharu Yajima and Seiichiro Tomioka and Kazutoshi Komatsu and Kazuyoshi Tsukamoto and Koichi Matsumoto and Satoshi Saito and Katsuo Kanmatsuse},
  year={2004}
}
The present study was undertaken to evaluate the role of sarthran-sensitive receptor within the rostral ventrolateral medulla (RVLM) in acute and chronic N ω -nitro-L-arginine methyl ester (L-NAME)-induced hypertension. Adult male Sprague-Dawley rats were given L-NAME subcutaneously via an osmotic mini-pump. After 2 weeks, rats were anesthetized with α-chloralose and injected bilaterally with sarthran into the RVLM. The chronic L-NAME treatment increased the arterial pressure (AP) to 153 ′ 2… CONTINUE READING

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