Inhibition of salivary secretion by lipopolysaccharide: possible role of prostaglandins.

@article{Lomniczi2001InhibitionOS,
  title={Inhibition of salivary secretion by lipopolysaccharide: possible role of prostaglandins.},
  author={Alejandro Lomniczi and Christiane Mohn and Alicia Graciela Faletti and Alessandro Franchi and S M Mccann and Val{\'e}ria Rettori and Juan Carlos Elverd{\'i}n},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={281 2},
  pages={
          E405-11
        }
}
Inducible (calcium-independent) nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are important in the regulation of the function of different organs during infection. A single dose of lipopolysaccharide (LPS; 5 mg/kg ip) within 6 h increased NOS activity (20%) and prostaglandin E (PGE) content (100%) in submandibular glands (SMG) and blocked stimulated salivary secretion in adult male rats. The administration of an iNOS synthesis inhibitor, aminoguanidine (AG), with LPS decreased NOS… CONTINUE READING
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