Inhibition of salivary secretion by lipopolysaccharide: possible role of prostaglandins.

  title={Inhibition of salivary secretion by lipopolysaccharide: possible role of prostaglandins.},
  author={Alejandro Lomniczi and Christiane Mohn and Alicia Graciela Faletti and Alessandro Franchi and S M Mccann and Val{\'e}ria Rettori and Juan Carlos Elverd{\'i}n},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={281 2},
Inducible (calcium-independent) nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are important in the regulation of the function of different organs during infection. A single dose of lipopolysaccharide (LPS; 5 mg/kg ip) within 6 h increased NOS activity (20%) and prostaglandin E (PGE) content (100%) in submandibular glands (SMG) and blocked stimulated salivary secretion in adult male rats. The administration of an iNOS synthesis inhibitor, aminoguanidine (AG), with LPS decreased NOS… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 22 references

Interaction between nitric oxide and prostaglandin E after acute lipopolysaccharide administration

A Lomniczi, C Mohn, +3 authors V. Rettori
The Endocrine Society’s 82nd Annual Meeting, • 2000
View 11 Excerpts
Highly Influenced

Role of nitric oxide in salivary secretion.

Neuroimmunomodulation • 1998
View 6 Excerpts
Highly Influenced

Microstructure of mammalian salivary glands and its relationship to diet

B Tandler, CJ Phillips
Oral Frontiers on Biology, • 1998
View 1 Excerpt

Nitric oxide synthase content of hypothalamic explants: increase by norepinephrine and inactivated by NO and cGMP.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 1 Excerpt