Inhibition of salivary secretion by activation of cannabinoid receptors.

  title={Inhibition of salivary secretion by activation of cannabinoid receptors.},
  author={Juan Pablo Prestifilippo and Javier Fern{\'a}ndez-Solari and Carolina de la Cal and Mar{\'i}a Iribarne and Angela Mar{\'i}a Suburo and Val{\'e}ria Rettori and S M Mccann and Juan Carlos Elverd{\'i}n},
  journal={Experimental biology and medicine},
  volume={231 8},
It is known that marijuana use decreases saliva secretion. Therefore, we hypothesized that cannabinoid receptors (CBs) are located in salivary glands to mediate that effect. In these experiments, we used the submandibular gland (SMG) of male rats, which is one of the major salivary glands. Mammalian tissues contain at least two types of CBs, CB1 and CB2, mainly located in the nervous system and peripheral tissues, respectively. Both receptors are coupled to Gi protein and respond by inhibiting… CONTINUE READING


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