Inhibition of ryanodine receptors by 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in canine pulmonary arterial smooth muscle cells.

@article{Ostrovskaya2007InhibitionOR,
  title={Inhibition of ryanodine receptors by 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in canine pulmonary arterial smooth muscle cells.},
  author={Olga Ostrovskaya and Ravi Goyal and Norazleen Osman and Claire E. McAllister and Isaac N Pessah and Joseph R. Hume and Sean M. W. Wilson},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={323 1},
  pages={
          381-90
        }
}
Ryanodine is a selective ryanodine receptor (RyR) blocker, with binding dependent on RyR opening. In whole-cell studies, ryanodine binding can lock the RyR in an open-conductance state, short-circuiting the sarcoplasmic reticulum, which restricts studies of inositol-1,4,5-trisphosphate receptor (InsP3R) activity. Other RyR blockers have nonselective effects that also limit their utility. 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) blocks RyR-elicited Ca2+ increases in skeletal… CONTINUE READING
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