Inhibition of rho-associated kinase reduces MLC20 phosphorylation and contractility of intact myometrium and attenuates agonist-induced Ca2+ sensitization of force of permeabilized rat myometrium.

Abstract

The role of rhoA/rho-associated kinase (ROK) signaling pathways in agonist-induced contraction of the rat myometrium was investigated. We measured the [Ca(2+)](i)-force relationship, phosphorylation of myosin regulatory light chains (MLC(20)) in intact tissue and the Ca(2+)-sensitization of force in permeabilized myometrial cells of rat. In measurements of… (More)

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@article{Oh2003InhibitionOR, title={Inhibition of rho-associated kinase reduces MLC20 phosphorylation and contractility of intact myometrium and attenuates agonist-induced Ca2+ sensitization of force of permeabilized rat myometrium.}, author={Jae-Hwan Oh and S You and Mi-kyung Hwang and Duck-Sun Ahn and Seong-chun Kwon and Michael J. Taggart and Young-Ho Lee}, journal={The Journal of veterinary medical science}, year={2003}, volume={65 1}, pages={43-50} }