Inhibition of reverse transcriptase activity increases stability of the HIV-1 core.

@article{Yang2013InhibitionOR,
  title={Inhibition of reverse transcriptase activity increases stability of the HIV-1 core.},
  author={Yang Yang and Thomas Fricke and Felipe D{\'i}az-Griffero},
  journal={Journal of virology},
  year={2013},
  volume={87 1},
  pages={
          683-7
        }
}
Previous studies showed that HIV-1 reverse transcription occurs during or before uncoating, linking mechanistically reverse transcription with uncoating. Here we show that inhibition of reverse transcriptase (RT) during HIV-1 infection by pharmacologic or genetic means increased the stability of the HIV-1 core during infection. Interestingly, HIV-1 particles with increased core stability were resistant to the core-destabilizing effects of rhesus TRIM5α (TRIM5α(rh)). Collectively, this work… CONTINUE READING

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