Inhibition of retinal neovascularization by soluble EphA2 receptor.

  title={Inhibition of retinal neovascularization by soluble EphA2 receptor.},
  author={Jin Chen and Donna J. Hicks and Dana M. Brantley-Sieders and Nikki C. K. Cheng and Gary W. McCollum and Xiang Qi-Werdich and John Penn},
  journal={Experimental eye research},
  volume={82 4},
Eph receptor tyrosine kinases (RTKs) and their ligands, known as ephrins, play an important role in vascular remodeling during embryogenesis, but their functions in adult angiogenesis are just beginning to be investigated. In this report, we investigated the effect of blocking EphA receptor activation on VEGF-induced angiogenic responses of cultured retinal endothelial cells and on retinal neovascularization in a rodent model of retinopathy of prematurity (ROP). Soluble EphA2-Fc receptors… CONTINUE READING


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