Inhibition of respiratory viruses by nasally administered siRNA

  title={Inhibition of respiratory viruses by nasally administered siRNA},
  author={Vira Bitko and Alla Musiyenko and Olena Shulyayeva and S. Barik},
  journal={Nature Medicine},
Respiratory syncytial virus (RSV) and parainfluenza virus (PIV) are two respiratory pathogens of paramount medical significance that exert high mortality. At present, there is no reliable vaccine or antiviral drug against either virus. Using an RNA interference (RNAi) approach, we show that individual as well as joint infection by RSV and PIV can be specifically prevented and inhibited by short interfering RNAs (siRNAs), instilled intranasally in the mouse, with or without transfection reagents… CONTINUE READING
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Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition

  • Das, A.T
  • J. Virol
  • 2004

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