Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA.

@article{Lo1992InhibitionOR,
  title={Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA.},
  author={K M Lo and Maria Angela Biasolo and Ghassan Dehni and Giorgio Pal{\`u} and William A. Haseltine},
  journal={Virology},
  year={1992},
  volume={190 1},
  pages={176-83}
}
A ribozyme was constructed that specifically cleaves RNA that contains the first coding exon of the tat gene of HIV-1. This anti-tat ribozyme was incorporated into a Moloney murine leukemia virus vector. A sequence containing only the 48-nucleotide antisense region of the ribozyme was also inserted into the retroviral vector. Human T-cell lines constitutively producing the tat-antisense and the anti-tat ribozyme RNA were created by transduction into Jurkat cells. When challenged with HIV-1… CONTINUE READING

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