Inhibition of renin-angiotensin system (RAS) reduces ventricular tachycardia risk by altering connexin43

Abstract

Renin-angiotensin system (RAS) activation is associated with arrhythmias. We investigated the effects of RAS inhibition in cardiac-specific angiotensin-converting enzyme (ACE) overexpression (ACE 8/8) mice, which exhibit proclivity to ventricular tachycardia (VT) and sudden death because of reduced connexin43 (Cx43). ACE 8/8 mice were treated with an ACE… (More)
DOI: 10.1007/s00109-011-0761-3

8 Figures and Tables

Topics

Statistics

020406020112012201320142015201620172018
Citations per Year

140 Citations

Semantic Scholar estimates that this publication has 140 citations based on the available data.

See our FAQ for additional information.

  • Presentations referencing similar topics