Inhibition of renin-angiotensin system (RAS) reduces ventricular tachycardia risk by altering connexin43


Renin-angiotensin system (RAS) activation is associated with arrhythmias. We investigated the effects of RAS inhibition in cardiac-specific angiotensin-converting enzyme (ACE) overexpression (ACE 8/8) mice, which exhibit proclivity to ventricular tachycardia (VT) and sudden death because of reduced connexin43 (Cx43). ACE 8/8 mice were treated with an ACE… (More)
DOI: 10.1007/s00109-011-0761-3

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